LOCUS FJ515781 17745 bp DNA circular MAM 10-FEB-2009 DEFINITION Thylacinus cynocephalus mitochondrion, complete genome. ACCESSION FJ515781 VERSION FJ515781.1 GI:218135488 KEYWORDS . SOURCE mitochondrion Thylacinus cynocephalus (Tasmanian wolf) ORGANISM Thylacinus cynocephalus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Thylacinidae; Thylacinus. REFERENCE 1 (bases 1 to 17745) AUTHORS Miller,W., Drautz,D.I., Janecka,J.E., Lesk,A.M., Ratan,A., Tomsho,L.P., Packard,M., Zhang,Y., McClellan,L.R., Qi,J., Zhao,F., Gilbert,M.T., Dalen,L., Arsuaga,J.L., Ericson,P.G., Huson,D.H., Helgen,K.M., Murphy,W.J., Gotherstrom,A. and Schuster,S.C. TITLE The mitochondrial genome sequence of the Tasmanian tiger (Thylacinus cynocephalus) JOURNAL Genome Res. 19 (2), 213-220 (2009) PUBMED 19139089 REFERENCE 2 (bases 1 to 17745) AUTHORS Schuster,S.C. and Miller,W. TITLE Direct Submission JOURNAL Submitted (03-DEC-2008) Center for Comparative Genomics and Bioinformatics, Penn State University, 310 Wartik Building, University Park, PA 16803, USA FEATURES Location/Qualifiers source 1..17745 /organism="Thylacinus cynocephalus" /organelle="mitochondrion" /mol_type="genomic DNA" /specimen_voucher="NRM 566599" /db_xref="taxon:9275" /note="died at the London Zoo in 1893; assumed to be female" tRNA 600..667 /product="tRNA-Phe" rRNA 668..1619 /product="12S ribosomal RNA" tRNA 1621..1688 /product="tRNA-Val" rRNA 1689..3255 /product="16S ribosomal RNA" tRNA 3260..3333 /product="tRNA-Leu" gene 3335..4291 /gene="ND1" CDS 3335..4291 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="ACK57344.1" /db_xref="GI:218135495" /translation="MFTLNLFLYIIPILLAVAFLTLIERKVLGYMQFRKGPNIVGPYG LLQPFADAIKLFTKEPLQPLTSSWSMFILAPILALTIALTIWTPLPMPNALLDLNLGL LFILSMSGLSVYSILWSGWASNSKYALVGALRAVAQTISYEVTLAIILLSVMLINGSY TMKTLSITQENLWLIFTTWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYASG PFAMFFLAEYANIIAMNALTTILFLGSSMSLLTPNINTLIFVIKTLLLTITFLWIRAS YPRFRYDQLMYLLWKNFLPLTLALCLWFISMPISMSCIAPQM" tRNA complement(4291..4359) /product="tRNA-Ile" tRNA 4357..4427 /product="tRNA-Gln" tRNA 4427..4494 /product="tRNA-Met" gene 4496..5539 /gene="ND2" CDS 4496..5539 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="ACK57345.1" /db_xref="GI:218135496" /translation="MSPYTLTMVSLSLFLGTCLTLSSNHWFTAWMGLEINTLAIMPVM TSPNNPRSTEATTKYFLTQATASMIMMFAIVYNAWTTDQWTMFNLSDDWASTFMTIAL AMKLGLAPFHLWVPEVTQGIPLLSGMILLTWQKIAPTSILYQISPCLNMEIMMSLAIL SAILGGWGGLNQTHLRKILAYSSITHMGWMTIIVNINPTLTVVALIIYMAATITLFMT LNYSTITKIKSLANLWNKSAPIAFIIMLTLLSLGGLPPLSGFSPKWLILHELASNNNA VAAIVMALSALLNLFFYMRIMYVSTLTIFPYTNTCKMQWYFNSTKPTCTIPTMTIISF LLLPLTPMFSIFM" tRNA complement(5541..5609) /product="tRNA-Ala" tRNA complement(5615..5680) /product="tRNA-Cys" tRNA 5698..5767 /product="tRNA-Trp" tRNA complement(5824..5895) /product="tRNA-Asn" tRNA complement(5900..5964) /product="tRNA-Tyr" gene 5966..7507 /gene="COX1" CDS 5966..7507 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="ACK57340.1" /db_xref="GI:218135491" /translation="MFINRWLFSTNHKDIGTLYLLFGAWAGMIGTALSLLIRAELGQP GTLIGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSTIEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGISSILG AINFITTIINMKPPALSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVTYYAGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMMWSLGFIFLFTIGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FVHWFPLFTGYTLNEMWAKIHFSIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTAW NVLSSIGSFISLTAVILMIFIVWEAFASKREVSKVEMTMTNIEWLYGCPPPYHTFEQP VFIKI" tRNA complement(7509..7577) /product="tRNA-Ser" tRNA 7581..7650 /product="tRNA-Asp" gene 7652..8333 /gene="COX2" CDS 7652..8333 /gene="COX2" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:8333,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="ACK57341.1" /db_xref="GI:218135492" /translation="MPYPTQLGLQDATSPIMEELMYFHDHTLMIVFLISSLVLYVLLL MLTTKLTHTSTMDAQEVETIWTIMPAVILVLIALPSLRILYMMDEIFNPYITVKAIGH QWYWSYEYTDYDNLSFDSYMVPTQDLLPGQFRLLEVDNRMVLPMELPIRMLISSEDVL HAWAVPSLGLKADAVPGRLNQATLTSTRPGVYYGQCSEICGSNHSFMPIVLEMTTLKY FVKWSWLMQ" tRNA 8334..8398 /product="tRNA-Lys" gene 8401..8610 /gene="ATP8" CDS 8401..8610 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="ACK57339.1" /db_xref="GI:218135490" /translation="MPQLNTTSWFFVISIATLSLFCIFQLNLVGIEMIYIYPPEEVLK LPEIPFPWEKKWTKIYLPLSSVLTS" gene 8565..9245 /gene="ATP6" CDS 8565..9245 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="ACK57338.1" /db_xref="GI:218135489" /translation="MNKNLFASFICPNIMGLSTLPIIIMLPCLMFTAPKRWLPNRIQI LQIWLIRLITKQMMSMHSKLGRTWSLMLISLILFIASTNLLGLLPYSFTPTTQLSMNL GMAIPLWMGTVILGLRKKPKASLAHFLPQGTPTPLIPMLIIIETISLFIQPIALAVRL TANITAGHLLMHLIGSATLALASINIMISSITFTILLLLTILELAVAIIQAYVFTLLV SLYLHDNS" gene 9245..10028 /gene="COX3" CDS 9245..10028 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10028,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="ACK57342.1" /db_xref="GI:218135493" /translation="MAHQTHAYHMVNPSPWPLTGALSALLLTSGLAMWFHFHSLTLIM FGLTSMLLTMFQWWRDIVREGTYQGHHTPVVQKGLRYGMILFITSEIFFFLGFFWAFY HSSLSPALELGGCWPPTGVRPLNPLEVPLLNTAILLASGVSITWAHHSLMESNRKQTI QALSVTIILGLYFTILQATEYYEAPFTISDGIYGSTFFVATGFHGLHVIIGSLFLMVC LMRQLFYHFTSTHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" tRNA 10029..10096 /product="tRNA-Gly" gene 10097..10442 /gene="ND3" CDS 10097..10442 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10442,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="ACK57346.1" /db_xref="GI:218135497" /translation="MNLILMLIINFSLATIVVLIAFWLPQLYLYLEKSSPYECGFDPL GSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAMQLTSTKTTLILSYSLIILLTSGL AYEWFQKGLEWTE" tRNA 10443..10511 /product="tRNA-Arg" gene 10512..10808 /gene="ND4L" CDS 10512..10808 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="ACK57348.1" /db_xref="GI:218135499" /translation="MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMM ALLITQFHMFSISMIPLILLVFSACEAGVGLALLVKISGTHGNDHIHNLNLLQC" gene 10802..12179 /gene="ND4" CDS 10802..12179 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12179,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="ACK57347.1" /db_xref="GI:218135498" /translation="MLKILIPTLMLIPLTWLSKKPWLWTNLTVHSLLISVWSLTLLNN SMDLGYNYNNSMFIDSLSSPLIVLSCWLLPLMIIASQNHLMDEPSNRKKTYLTMLIIL QLSLIMAFSSSELIMFYIMFESTLIPTLIIITRWGNQNERLNAGIYFIFYTLTGSLPL LVALIYLYHKMGSLHMPMMSIMNMTLDSSMSSSLLWYACMMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGIMRMTAFTEPLTTNLCYPFMTLSMWGMVMTSSIC MRQTDLKALIAYSSVSHMALVIVAALMQTPMSFMAATTLMIAHGLTSSMLFCLANSNY ERIHSRTLLLARGLQTVLPLMCTWWLIASLANLALPPSINLIGELMVIMTSFSWSNMT IILLGINTVITALYSMYMFTTSQRGKLSQHLYSTKPTLTREHLLMVLHLIPLLIMSIN PKFILGPTY" tRNA 12180..12249 /product="tRNA-His" tRNA 12249..12307 /product="tRNA-Ser" tRNA 12308..12378 /product="tRNA-Leu" gene 12370..14193 /gene="ND5" CDS 12370..14193 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="ACK57349.1" /db_xref="GI:218135500" /translation="MKVINHIFNSMLIMSIITLMSPLAYNMINPNKTTNFPSLCKNAV KSAFFMSLIPLTLFIHMDQESMVTNWQWLSLGTLTINMSFKMDYFSVVFLPIALYITW SIMEFSMWYMHSDPDIHRFSKYLIMFLLTMTILVSANNLFQLFIGWEGVGIMSFMLIG WWYGRTDANTAAMQAILYNRIGDIGFMLSMAWFMMNNNSWNLQHIFMTDIDSLALMGL IIAAAGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLLEKNQMAL TMTLCLGAITTLFTAICAITQNDIKKIVAFSTSSQLGLMMVTMGLNQPHLAFLHICTH AFFKALLFMCSGSIIHSLNNEQDIRKMGGLLKLLPITSSATILGSMALTGMPFLSGFY SKDSIIEALNTSYINSWALSITLIATMTTAMYSMRMISLALLEEPRFTTMSPINENNP NLIKPIMRLTLGSIFAGFFITMNIPPTIVIPMAMPMSTKLCALTVSILGIVIMLELSY LANNMHNISIKHSYYFSNSLGYFSFIFHRLNPMMSLLLGQHIATLLIDLNWFEKTGPK GQTNLHTYSSSSITSTQKGMMKTYFLSFLISMILMLPITLL" gene complement(14188..14688) /gene="ND6" CDS complement(14188..14688) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="ACK57350.1" /db_xref="GI:218135501" /translation="MKMMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIV VSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYPESWVGNLVAFSMLVFAFLTELL WYMMSGEILAVYNMELLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWVLFMTILVIL EIVRGL" tRNA complement(14692..14760) /product="tRNA-Glu" gene 14764..15906 /gene="CYTB" CDS 14764..15906 /gene="CYTB" /codon_start=1 /transl_table=2 /product="cytochrome b" /protein_id="ACK57343.1" /db_xref="GI:218135494" /translation="MKILRKTHPILKTINHSFIDLPTPSNISAWWNFGSLLGICLVIQ ILTGLFLAMHYTSDTSTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCMFLHVGRGI YYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTL VEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLIFLHETGSNNPSGINPNSDKI PFHPYYTIKDILGLMIMLFILISLALFSPDMLGDPDNFSPANPLNTPPHIKPEWYFLF AYAILRSIPNKLGGVLALITSILILLIIPMLHTSNQRSMMFRPFSQTLFWILTANLLT LTWIGGQPVEQPFIIIGQLASIMYFLTIIILMPLAGLLENYMLEPK" tRNA 15909..15976 /product="tRNA-Thr" tRNA complement(15981..16047) /product="tRNA-Pro" ORIGIN 1 gtacacacgt atatgcgtac acacgtgtat gcgtacgtgt acgtgtacgt gtaaataata 61 attaataact aattaataat aataaataat aataaataat aaataataat aaataataaa 121 taataataaa taataataaa taataaataa taataaataa taataaataa taatatataa 181 taatataaaa taatatataa taaataataa taagtttctg atcattaaac cccccctacc 241 ccccttacta aattttatcg cttccgtcaa acccctaaac cggatgatag acctttagca 301 caatgaataa tcatcgtacg ggagaaaaca ttctaaaccc aaatactatt tacatttaac 361 ttattaccta atcaaattaa ctaaccaaaa acaattaact aaccaaaaac aattaactaa 421 ccaaaaacaa ttaactaacc aaaaacaatt aactaaccaa aaacaattaa ctaaccaaaa 481 acaattaact aaccaaaaat tttctgattc aaaaagaaaa aaaaaaaaaa aaaaaaaaaa 541 aaaaaattta atactgacat agtatataaa ttaaaaattt caaaaaaaaa ttactttttg 601 tttgtgtagc ttaaccaaag caaagcactg aaaatgcttc gatggatcat aatgggtccc 661 agaaacacaa aggtttggtc ctggccttac tgttaattct tattagacct acacatgcaa 721 gtttccgcgc cccagtgaga atgccctcaa aactaactaa tagtttttta ggagtgggta 781 tcaggcacac tcaatgagta gcccatgaca ccttgcctag ccacgccccc acgggataca 841 gcagtgacta atattgagct atgaacgaaa gtttgactaa attataataa agagggttgg 901 tcaatatcgt gccagccacc gcggtcatac gattaaccca agttaacaga aaaacggtgt 961 aaagcgtgtt taagcgaaat aaataaaata aagttaatac ctgactaagc tgtaatacgc 1021 catagttagt actaaaatac acaactaacg tgactttact atagagctga agacactaaa 1081 gctaaggtac aaactgggat tagatacccc actatgctta gccataaact taggtagtcg 1141 aataacgaga ctactcgcca gagaactacg agccactgct taaaactcaa aggacttggc 1201 ggtgccctaa acccttctag aggagcctgt tctataatcg ataaaccccg atacacctca 1261 ccccttctag ctctatcagt ctatataccg ccatcgtcag ctcaccccaa caggggacaa 1321 aagtgagcaa gattatgaaa ccataaaaac gttaggtcaa ggtgtagcgt atggaggggg 1381 aagcgatggg ctacattttc taaattagaa cataacgaat tatctattga aacaaagata 1441 tgaaggagga tttagtagta aattaagaat agagagctta attgaaaaag gcaatggggt 1501 gcgtacacac cgcccgtcac cctcctcgaa aaagtattaa accattcata atacaattac 1561 gataaaaaga ggagaaaagt cgtaacatgg taagtgtact ggaaggtgca cttggaacac 1621 caaaatgtag cttaaataaa gcatttagct tacacctaaa agatttcagc ttatactgac 1681 cattttgagc taaacctagt cctaccatta aacaacttaa ctatatccaa taatactcca 1741 aatcatttaa tagactaagt ataggtgata gaacagaatt ataaggaacg ataacgacag 1801 taccgcaagg gaaatttgaa atattattat tttcaagcaa tagaaagcaa agattcagcc 1861 ttgtaccttt tgtataatga tttagctagt caacacggac aaaaagaatt taagcccgtc 1921 ttcccgaaat taagtgagct attataggac tgttggcaga actaactcgt ctatgtggca 1981 aaatagtgag atgatcttat aatagaggtg ataagcctat cgaacttaag gatagctggt 2041 tgtccaaaac acgaatttaa gttcgaattt aaatttaact aaagtatatg caaacacaac 2101 ttaaatttaa attataatca aaagggggac aacccttttg acatgaagac aaactttaac 2161 agagggtaat gaaaacctaa caaagcatag taggcctaga agcagccatc aattaagata 2221 gcgttaaagc tcaaattaaa ctaatattaa atacctataa tttatcaaaa cccctaatct 2281 aatattggac aattctataa ttttatagaa gatataatgc taatattagt aacatgaact 2341 aatttctcct agcatagact taaactcagt tcggaagcac cactagtaat taacaaacaa 2401 aataattaaa cccataatca agttttatat ttattctatt gttaacccaa cacaggcatg 2461 cataaatgga aagattaaaa ggaataaaag gaactcggca aacaaaaacc ccgcctgttt 2521 accaaaaaca tcacctctag cattaccagt attagaggca ctgcctgccc ggtgagttat 2581 aactttaacg gccgcggtat cctgaccgtg caaaggtagc ataatcactt gtcttttaaa 2641 tagagactag tatgaatggc atgacgaggg tttatctgtc tcttatttct aatcagtgaa 2701 attgaccttc ccgtgaagag gcgggaatat ctatacaaga cgagaagacc ctgcggagct 2761 taagacacct aactcaacta ttacccttat accctaaagg aacaaaaggt aaaccaactg 2821 agttaaagtc tttggttggg gtgacctcgg agcataaaag aacctccgaa tgattaataa 2881 ccaagattta cttttctaag tgtatgacta ccagtaattg acccatcaat tgatcaacga 2941 aataagttac cccagggata acagcgctat cctattcaag agcccatatc gaaaattagg 3001 gtttacgacc tcgatgttgg atcaggactc ccaaatggtg cagaagctat taacggttcg 3061 tttgttcaac gattaaagtc ctacgtgatc tgagttcaga ccggagaaat ccaggtcggt 3121 ttctatctgt aatttactcc tcccagtacg aaaggacaag agaagtaggg cctacactgc 3181 aagcaagccc tagagccaaa atatgaacta atctaaatat tataacttta tttattccaa 3241 cctaagaata gaggtaaaag ttaagatgac agagttggta attgtataaa gcttaagtct 3301 ttaatcccag aggttcaaac cctcttctta acatgtgttt acccttaatt tattcctgta 3361 tattattcca atcctattag cagtagcttt tctaacttta atcgaacgaa aagttctagg 3421 ttatatacaa tttcgaaaag ggccaaacat tgtaggacca tatggattac ttcaaccatt 3481 cgctgatgca attaaattat tcactaaaga acctcttcaa cctcttacat cttcctgatc 3541 tatatttatc ttagccccaa ttttagcact taccattgcc ctaacaatct gaaccccact 3601 acccatacca aatgcacttc tagacttaaa cctgggtcta ttgtttattc tctctatatc 3661 aggcctatca gtatactcga tcctatgatc aggatgagca tccaattcaa aatacgcttt 3721 agtaggagct ctacgagctg tagcccaaac aatctcatat gaagttacac tagcaattat 3781 tctattatcc gttatactaa ttaatggttc ttacaccata aaaactcttt ctatcacaca 3841 agaaaactta tgactgattt ttacaacatg acctttagct ataatatgat ttatctcaac 3901 cctagcagag actaatcgag ctccctttga cttaacagaa ggggaatctg aactagtatc 3961 aggatttaac gttgaatacg catcaggccc atttgccata ttctttctag cagaatatgc 4021 taatatcatc gccataaatg ccttaacaac tattttattt ttaggttcat ctataagcct 4081 attaactcct aatattaata ccttaatttt tgtgatcaaa actcttctac taactatcac 4141 attcttatga atccgagctt cgtatcctcg ctttcgatac gaccaactta tatacctcct 4201 atgaaaaaat ttcttacctt taacattagc tctatgccta tgatttatct ctataccaat 4261 ttcaatgtca tgcattgcgc cacaaatata agaaacatgt ctgataaaag aattatcttg 4321 ataggataaa aaataggggt gcaagccccc ttgtttctag aaaaacagga ctcgaaccta 4381 catttgagaa tccaaaactc tctgtgtttc ccttacacta tattctagta aggtcagcta 4441 aataagctat cgggcccata ccccgaaaat gttggtcctt atccttccct tactaatgtc 4501 accatacaca ttgaccatag tatcattaag cctattcctc ggtacatgct taaccctctc 4561 gagtaatcac tgattcacag catgaatagg actagagatt aacactttag ctatcatgcc 4621 tgttatgaca agccctaata atccacgctc tacagaagca actacaaaat acttcctaac 4681 ccaagccact gcttcaataa ttataatgtt tgctatcgta tataatgcat ggacaaccga 4741 tcaatgaact atattcaatt tatcggatga ctgagcctca acattcataa ctattgctct 4801 agccataaaa ctaggactag ctccatttca cctgtgagta cctgaagtaa cacaaggaat 4861 cccattattg tcaggtataa ttcttttaac ctgacaaaaa attgccccaa catccattct 4921 ttaccaaatt tcaccatgtc taaatataga gattataata tcattagcca tcttatcagc 4981 cattttaggc ggatgaggag gacttaatca aactcaccta cgaaaaattc tagcttattc 5041 atcaattacc catataggtt gaataactat cattgtaaat attaatccta ctctaacagt 5101 agttgcctta attatctata tagcagccac cattacccta tttatgacac taaattactc 5161 taccattact aaaattaaat cactagctaa tctgtgaaat aaatctgctc caattgcttt 5221 tatcattatg cttacactcc tatctctagg aggactacct ccactatccg ggttctcacc 5281 taagtgactt attttacatg aactagcttc aaacaataat gcagttgctg ctattgtcat 5341 agccctatca gccctactaa atcttttctt ttacatacga attatatacg tatcaaccct 5401 aaccatcttc ccgtacacta acacctgtaa aatacaatga tattttaatt caacaaaacc 5461 aacctgcact attccaacaa taactattat ttctttctta cttctccccc ttacaccaat 5521 attttcaatc ttcatgtagc taagaactac aaggatttat cctgcatcac ttgaacgcaa 5581 atcaagcact ttaattaagc taagtcctta aattagactt cggcagcatt taatctgctt 5641 cttcgaattt gcaattcaac gtaatatata cttcgaagcc gtccataaca accccaaaaa 5701 ggcttaggat aaacttagac cgaaggcctt caaagcctta agcagatgta taatcgtcta 5761 gcctttgaac caacttaaat tattatttaa acttaattaa ctaacattta taaacccata 5821 atactaaact ggaaggtatt tatcctacta aatcttagtt aacagctaag cgcctaaaca 5881 tccggcctca gtttattggt aaaaagaggc aattaacctc tgtctttgaa tttacagtcc 5941 aatgcttaac tcagccattt tacctatgtt cattaaccgc tgactattct ctactaacca 6001 taaagacatc ggtactttat accttctatt tggcgcttga gcgggtataa tcggaacagc 6061 acttagcctg ttaatccggg cagaattagg tcaaccaggt accctaattg gagacgatca 6121 aatctataac gttatcgtta cagcccacgc attcgtaata atctttttta tagtaatacc 6181 cattataatt ggagggtttg gtaactgatt agttccacta ataatcggag ctccagatat 6241 agccttccca cgaataaaca acataagctt ttgacttctt ccaccctctt tccttttact 6301 cctagcatcc tctacaattg aagctggagc tggaactgga tggactgtat accctccctt 6361 agcaggaaat ctagcccatg caggagcctc agtagattta gcaatcttct ctcttcacct 6421 agccggtatc tcatctattc taggggctat taatttcatc acaacaatta tcaatataaa 6481 acctccagcc ctatcccaat atcaaactcc attatttgtt tgatcagtga taattacagc 6541 agtacttcta ctcttatcct tacccgttct ggcagcaggc attacaatac tacttacgga 6601 ccgaaatctt aatacaacat tttttgaccc tgctggagga ggtgacccaa tcctttatca 6661 acatctattt tgattttttg gtcacccgga agtatacatc cttattttac caggattcgg 6721 cattatctcc catatcgtta cctattatgc cggaaaaaaa gaaccatttg gctacatagg 6781 catagtatga gcaataatat caattggctt ccttggattc attgtctgag cacatcacat 6841 attcactgta ggccttgatg tagatactcg agcatacttc acatcagcca ctataattat 6901 cgccatccct acaggcgtaa aagtatttag ctgattagcc acattacatg gaggtaacat 6961 taaatgatcc cccgctataa tatgatccct aggctttatc ttcctattca caatcggagg 7021 actaacagga atcgtactag ccaactcatc tcttgatatt gttctccacg acacatatta 7081 tgtagtagca catttccatt acgtcttatc cataggagct gttttcgcca ttataggagg 7141 tttcgtccat tgattccccc tatttacagg atacacactt aatgaaatat gagcaaaaat 7201 ccatttctca attatgtttg taggagtaaa cataacattc ttcccacaac actttttagg 7261 attatctggc atgcctcgac gatattcaga ctatccagat gcatacacag catgaaacgt 7321 cttatcttct atcggatcat ttatctcatt aacagccgta attttaataa ttttcatcgt 7381 ttgagaagca ttcgcatcaa aacgagaagt ttctaaagta gaaataacca taaccaatat 7441 tgaatgactt tatggttgtc cacccccata tcacacattt gaacaaccag ttttcattaa 7501 aatctaaaca agaaaggaag gaatcgaacc cccaaaaatt gatttcaagt caaccccata 7561 acctttatga ctttctcaga aagatattag taacaatcat tacataactt tgccatagtt 7621 aaattatagg ttacaaccct gtatatctta catgccgtat cctactcaac ttggccttca 7681 agacgctacc tctccaatta tagaggaact aatatacttt cacgaccata cattaataat 7741 tgtttttcta atcagctctc tagtactata cgtgcttcta ctaatattga caacaaaact 7801 gacccacaca agcactatgg atgctcaaga agtggaaaca atttgaacta tcataccagc 7861 cgtaatctta gttttaattg ctcttccatc tctacgaatc ctttatataa tagatgaaat 7921 ctttaaccca tatattaccg taaaagcaat tggccatcaa tggtactgaa gttatgagta 7981 tacggactat gacaacctat catttgattc ctacatagtt ccaactcaag acctcttgcc 8041 cggacaattt cgactgcttg aagtagataa tcgaatggtc ttaccaatag aactgcccat 8101 tcgaatactc atttcatcag aagatgtcct ccatgcatga gcagtaccat cactagggtt 8161 aaaagcagat gctgtacctg gacgactaaa ccaagcaacc ctaacctcaa cccgtccagg 8221 cgtatactac ggacaatgct cagaaatctg tggctcaaac cacagcttta tacctattgt 8281 cttagaaata actaccttaa aatactttgt aaaatgatca tgattaatac aatcattttt 8341 gagttgcaaa agcgtaatac ttaagtatta tatgagattt aacctctcct caaaaacaaa 8401 atgccacagc taaacacaac ttcctgattc ttcgtaatct ccatcgccac tttatcactt 8461 ttctgcattt ttcaacttaa ccttgtagga attgaaataa tctacattta tccaccagaa 8521 gaagttctta aactaccaga aattccattc ccttgagaaa aaaaatgaac aaaaatttat 8581 ttgcctcttt catctgtcct aacatcatag gactatctac attaccaatc attatcatat 8641 taccatgctt aatgttcaca gcccctaaac ggtgacttcc aaaccgtatt caaattttac 8701 aaatttgact catccgatta atcaccaagc aaataatgtc tatacatagt aagcttggcc 8761 gaacttgatc cttaatactt atttctctaa ttctattcat tgcatcaact aacttacttg 8821 gtctacttcc ctactcattt acccctacta cacaactttc gatgaatctc ggtatagcta 8881 ttccactctg aataggcaca gtaattctag gattacgaaa aaaacctaaa gcatctctag 8941 cccattttct ccctcaaggt acacctactc cacttatccc aatacttatt atcatcgaaa 9001 ccatcagtct attcatccaa ccaatcgcat tagcagtacg acttacagct aacattactg 9061 ctggccatct tttaatacac cttatcggct cagcaactct agcacttgcc tccattaaca 9121 ttataatctc atcaattact ttcactattc ttctattact tactattctt gaactagcag 9181 tagccatcat ccaagcatac gtatttaccc tattagttag cctttatcta catgacaact 9241 cctaatggct caccaaaccc atgcatacca tatagttaac ccaagtccat gaccccttac 9301 aggggcccta tcggctctac tgctaacctc cggactagca atatgattcc acttccattc 9361 attaacccta attatattcg ggcttacatc aatactcttg actatatttc aatgatgacg 9421 agacatcgta cgggaaggta catatcaagg ccaccataca cccgtggttc aaaaaggact 9481 tcgatatgga ataatcttat tcatcacatc agaaatcttt tttttcctag gctttttctg 9541 agctttctac cactcaagcc tatcacctgc tttagaacta ggaggctgct gaccaccaac 9601 aggagtacgc ccactaaacc cacttgaagt accacttctt aatacagcaa ttctactagc 9661 ctctggcgta tcaattacat gagctcatca cagtcttata gaaagtaatc gaaaacaaac 9721 aattcaagct ctttcagtga ctatcattct aggcttatat tttaccatcc ttcaagccac 9781 agaatattac gaagctccat ttacaatctc agacggcatt tatgggtcaa catttttcgt 9841 agcaacaggc tttcatggcc tacacgtcat tatcggctca ctattcctaa tagtatgctt 9901 aatacgacaa ttattctatc acttcacctc tactcaccac ttcggctttg aagccgccgc 9961 ttgatactga cacttcgtag acgtagtctg actattcctg tatgtttcca tttactgatg 10021 aggctcatgt ttttctagta taattagtac tactgatttc caatcattaa gttctgggca 10081 gtaccagaga aaaacaatta acctaatcct catactcatt atcaacttct cactggctac 10141 aattgttgtt ctaattgcct tctgactccc tcaattatat ttatacctag aaaaatcaag 10201 cccatacgaa tgtggctttg atccactagg ctccgcccga cttccattct caataaaatt 10261 tttcctagta gctattacat ttctattatt tgatttagaa atcgccctgt tacttccact 10321 accatgagcc atacaactaa catcaaccaa aactacgctc attctctcat actctctaat 10381 cattctactt acatcaggtc tcgcatatga atgatttcaa aaaggcttag aatgaactga 10441 ataggttttt aatctaatta agataattga tttcgactca ataaatcatg gtaatacccc 10501 atgaatacct tatgttacct atctacttta acctaactat aaccttttca ttagctctaa 10561 taggagtgtt aatttatcga tcacacataa tatcaacact tctatgttta gaaggcatga 10621 tattatcact attcatcata atagcacttc taattacaca atttcacata ttctcaattt 10681 ccataatccc actaatctta ctagtatttt cagcatgtga agcaggagtc ggcctagcac 10741 ttcttgtaaa aatttcagga acccacggaa atgaccacat tcataatcta aacttactcc 10801 aatgctaaaa atcctaattc ctacactcat actaattcca ttaacctgac tatccaaaaa 10861 accctgacta tgaaccaact taaccgttca tagtttattg attagtgtat gaagcctaac 10921 actactaaac aacagcatgg accttggtta caactacaac aactcaatat tcattgactc 10981 cttatctagc cctctaatcg tactatcatg ctgattactc ccactaataa ttattgctag 11041 ccaaaatcac ctaatagatg aaccatcaaa ccgaaaaaaa acatatctca ctatattaat 11101 tattcttcaa ctatctttaa ttatagcttt cagctcctca gaattaatta tattttatat 11161 tatatttgaa tctaccttga ttccaaccct aattattatt acacgatgag gtaaccaaaa 11221 cgaacgactc aatgcaggaa tttattttat tttctacact ctaaccggat ctctacccct 11281 actagtagcc ctaatctatt tataccacaa aataggatca ctacacatac ccataatatc 11341 aattataaat ataaccctcg attcttctat atcctcctca ctattatgat atgcatgcat 11401 aatagcattt atagttaaaa tacccttata tggcctacac ctatgattac caaaagccca 11461 cgttgaagcc ccaattgcag gatctatggt cctagccgcc gtccttctaa aactaggtgg 11521 atatgggatt atacgaataa cagccttcac agaaccttta acaactaatc tttgctaccc 11581 atttataaca ctatccatat gaggaatagt cataacaagc tctatttgca tacgacaaac 11641 agacttaaaa gcactaattg cttattcctc agtaagccat atagcattag taatcgtcgc 11701 cgcattaata caaacaccca taagctttat agcggccacc actctaataa ttgcccatgg 11761 acttacatca tccatactct tctgcttagc caactccaac tatgaacgaa ttcatagccg 11821 aactcttcta ctagcccgag gactacagac agttttacca cttatatgca cctgatgact 11881 cattgcaagc ctagctaacc tagccctacc cccatcaatt aacctcatcg gagaattaat 11941 agtaattata acttcatttt cttgatctaa catgactatt attcttctag gaattaacac 12001 agtgattaca gcactgtatt ccatatatat attcactact tcacaacgag gtaaacttag 12061 ccaacatctt tactcaacaa aacctacact tacccgagaa catttattaa tagttctaca 12121 tcttattccc ttactaatca tatctattaa tccaaaattt atcttaggac ccacatattg 12181 caaatatagt ttaacacaaa acattagact gtgaatctaa aaataggaat tcagaactcc 12241 ttatatgccg agaaagacat aagaactgct aattcctaat tccatggcta acaaccatgg 12301 ctttcttact tttaaaggat aacagccatc cattggtctt aggaatcaaa aattttggtg 12361 caactccaaa taaaagtaat taaccacatc tttaactcca tacttattat atcaattatt 12421 accctaatat ccccgctagc atataacata atcaacccaa acaaaactac aaactttcct 12481 tcattatgca aaaacgctgt aaaatcagcc ttttttataa gcttaattcc tcttaccctg 12541 tttatccata tagaccaaga atcaatagtc acaaactgac aatgattatc attaggaacc 12601 ttaaccatta atataagctt taaaatagac tatttctccg ttgtattctt acctattgct 12661 ctatacatca catgatcaat catagaattc tctatatgat atatacactc cgacccagac 12721 attcaccgat tctctaaata tctaattata tttcttctta ccataacaat tctagtatca 12781 gctaacaacc tattccaact attcattgga tgagaaggtg tagggattat gtctttcata 12841 ttaatcggat gatggtatgg acgcaccgat gcaaatacag cagccataca agccatcctt 12901 tacaaccgaa tcggagacat cggatttata ctgtctatag cctgatttat aataaataac 12961 aactcatgaa atttacaaca tatctttata actgatatcg actctctagc cctcatgggg 13021 cttatcattg cagccgccgg caaatcagcc caatttggcc ttcacccatg acttccatca 13081 gctatagaag gaccaacccc agtatcagca ttattacact ctagtacaat agtagtagct 13141 ggagtcttct tacttatccg attccaccca ttactagaaa aaaaccagat agccctaaca 13201 ataacattat gtcttggcgc tattacaaca ctatttaccg ctatctgcgc tattacccaa 13261 aacgacatta aaaaaatcgt agccttctct acatccagcc aactaggctt aataatagtg 13321 acaatgggat taaaccaacc acacctagca tttctacata tctgtaccca cgcctttttc 13381 aaagccttat tattcatatg ctccggctcc atcattcata gccttaacaa tgaacaagat 13441 attcgaaaaa taggaggact acttaaactt ctcccaatta catcttcagc tactatccta 13501 ggaagcatag ctctaacagg cataccattc ctatcaggat tttactcaaa agactctatc 13561 atcgaagctc ttaacacatc atacattaac tcctgagccc tatctattac attaattgcc 13621 accataacaa cagcaatata cagcatacga ataatcagcc tagctctcct agaagaacct 13681 cgatttacaa ctatatcacc tatcaacgaa aataatccaa acttaatcaa accaatcatg 13741 cgacttaccc taggtagcat cttcgctgga ttcttcatca caatgaatat tcctccaact 13801 attgttatcc caatagctat acctatatca acaaaactat gcgccttaac cgtttcaatc 13861 ctaggaatcg taatcatact agaactgagc tacttagcca acaatataca taatatctcc 13921 atcaaacatt cttactactt ctcaaactca ctaggctact tctcatttat cttccaccga 13981 cttaacccta taataagcct tctactagga cagcacattg ccaccttact tattgaccta 14041 aactgattcg aaaaaacagg acccaaagga caaaccaacc ttcacactta ttcatcttca 14101 tctattacct caactcaaaa aggaataata aaaacctact tcctatcctt cttaatttcc 14161 ataattctca tattaccaat cacactatta taagccacgc acaatttcta aaataactaa 14221 aatagttata aataaaaccc aacctaacag caccaaggct catcccccac aaccatataa 14281 ccacgacacc ccatttcaat cttgaccaac acaataatta cccaaagaat ccaataactc 14341 tatattatat acagccaaaa tctcaccaga cattatatat catagcaact cagtcaaaaa 14401 agcaaaaact aatatactaa aagccaccaa atttcctact caactttcag gatattcctc 14461 tgtagccata gcagccgtat acccaaaaac aaccaacatt cctcccaaat aaattaaaaa 14521 aacaattaaa cctaaaaaaa cattacctaa actaacaaca attccacaac caattcctcc 14581 actaattaca agacttaatc caccatatac aggagaaggc ttagaagcaa acgctacaaa 14641 tcccataacc aacattaaag aaagcaaaaa aattactatc attttcatat taattttagt 14701 atggactcta accataacct atgatacgaa aaaccattgt tgtaattcaa ctacaaaaac 14761 ctaatgaaaa tcttacgaaa aacccaccca atcctaaaaa ccattaacca ctcatttatt 14821 gacctaccaa caccctccaa catctcagcc tgatgaaact ttggatcctt actaggaatc 14881 tgcttagtca ttcaaatctt aacaggctta tttctagcaa tacattacac atcagacaca 14941 tcaactgcct tctcctcagt agcacatatc tgtcgagacg taaactatgg atgacttatc 15001 cgtaatctac atgctaatgg agcatccata ttcttcatat gcatgtttct tcatgtagga 15061 cgaggcattt actacggatc atacttgtac aaagaaacat gaaacattgg agttatcctc 15121 ctattaacag ttatagcaac tgctttcgta ggatatgtcc ttccctgagg acaaatatca 15181 ttttgaggag ccactgtaat taccaatctt ctatcagcca tcccctatat tggcaccaca 15241 ttagtagaat gaatttgagg cggattttca gtagacaagg ctacacttac acgattcttt 15301 gcattccatt ttatcctccc attcattatt actgcactag taatcgttca cctaattttc 15361 ctgcatgaaa caggatcaaa taatccttca ggcatcaatc caaactcaga caaaattcca 15421 tttcacccat actatacaat caaagacatt ttaggtttaa taatcatact atttatcctt 15481 atctcactag ccctattctc tccagatata ctcggagacc ctgacaactt ctcaccagct 15541 aatccactta acactccacc acatatcaaa ccagagtggt atttcctatt cgcctacgca 15601 atcctacgat caattccaaa caaattaggg ggagtcctag cactaattac atctatctta 15661 atcctactta ttattcccat acttcatacg tccaaccaac gaagcatgat attccgaccc 15721 ttctctcaaa cattattctg aatcttaact gccaatcttc taaccctaac ctgaattgga 15781 ggacaaccag ttgaacagcc atttatcatt attggtcaac tagcatcaat catatatttc 15841 ctaacaatca ttattcttat accactagca ggactactag aaaattacat actagaaccc 15901 aaataaaagt ccaagtaatt taatcaaaat actggtcttg taaaccagca atgaaggaaa 15961 catccttcct aggacaaaca tcaagaagaa ggcaccaaac cctaccttta actcccaaag 16021 ctaatattct aattaaacta cttcctgaaa ttttttttat tttttttatt ttttttattt 16081 ttttttattt tttttcattt gtatactatc tcagtattaa attttttgta aaatttttgc 16141 acgaataata atacattaca tcaaatatat aaagacattt atgtatatag agcattcatt 16201 ccttataccc attcatataa gcaagtataa ttacatcaaa tatataaaga catttatgta 16261 tatagagcat tcattcctta tacccattca tataagcaag tataattaca tcaaatatat 16321 aaagacattt atgtatatag agcattcatt ccttataccc attcatataa gcaagtataa 16381 ttacatcaaa tatataaaga catttatgta tatagagcat tcattcctta tactcattca 16441 tataagcaag tataattaca tcaaatatat aaagatattt atgtatatag agcattcatt 16501 tcttatactc attcatataa gcaagtacaa taaatcaatt aaacaagaca tactatatta 16561 attatgctat agattatatt gaacattagt atctttacct aatatttctc atatagtaca 16621 taatacataa tatgtatata ttacataata catagtctgt caacttacat agacatttca 16681 tctatgatct acgaccataa tcctttatcc tcaagcatat ctcaaccatt aggattacct 16741 tcatcctcaa ctcacgagag atcagcaact cggtcatttg tagatacgaa ctccttcaga 16801 gcaagcccat aaactgcgga cgaaccttta ctgctttgac tggctattgg ttgttacttc 16861 aggtccatta aatcctattc agctaaacca tgcttttcgt cgaggcattt gtgatggttg 16921 cagtgcggtt tggcctcata tcgcggcatc gtaatgactt aaccggcata aggtagattt 16981 taatttgggg gtggtttatc aacagggcgg gagcctgggg gacgccaaca aaatagttga 17041 cttacataac aagaagtact ggatattaac gatatagaca ttactcaaaa ctcctagctc 17101 gcacgactct atttcagcgg aaataaaatc aatgatctat agacataaaa ttaatcaaat 17161 catcagttac aacaatatca acatctaaga ctacatacaa tcaatttcac taagatcaat 17221 aatcaatgat cgatagacat aacatcaagt attactaaca tcataaagac atattattat 17281 acttcccccc ctgcaaacac gtatttacca tcaacgtttg cgtttacacg tatatgcgta 17341 cacacgtata tgcgtacaca cgtatatgcg tacacacgta tatgcgtaca cacgtatatg 17401 cgtacacacg tatatgcgta cacacgtata tgcgtacaca cgtatatgcg tacacacgta 17461 tatgcgtaca cacgtatatg cgtacacacg tatatgcgta cacacgtata tgcgtacaca 17521 cgtatatgcg tacacacgta tatgcgtaca cacgtatatg cgtacacacg tatatgcgta 17581 cacacgtata tgcgtacaca cgtatatgcg tacacacgta tatgcgtaca cacgtatatg 17641 cgtacacacg tatatgcgta cacacgtata tgcgtacaca cgtatatgcg tacacacgta 17701 tatgcgtaca cacgtatatg cgtacacacg tatatgcgta cacac